Group Leader
Shashi B. Pandit
My group is engaged in deciphering the role of structural features in determining protein molecular function. We also integrate and analyse the complex, dynamic interactions of biological networks.
People
Current and past group members
A list of current and past members of the group.
PhD Researcher
Deepanshi Awasthi
DST-INSPIRE / GATE / CSIR-NET (LS) / PMRF
I work on the computational identification of proteogenomic events by integrating transcriptomic variation with mass-spectrometry peptidomics.
Interests
trekking, cooking
PhD Researcher
N. Rupesh
CSIR-NET (LS) / GATE / DBT Category II
I focus on the junctions where protein domains interact and explore their topological coherence and symmetry.
Interests
Trekking, Playing Badminton, Watching Cricket, Movies and TV Series, Debating Philosophical, Religious and Political Matters, Running and Sketching
PhD Researcher
Sadanandan Pichandi
GATE / DBT Category I
I study the structural and functional consequences of mutually exclusive exons in alternative splicing. I also work on computational design of single-domain antibodies and prediction of their interactions with target epitopes.
Interests
Politics, Sitcoms, Sketching, Non-fiction reading, and strength training and cycling
PhD Researcher
Ashmita Singh
GATE / Inspire
I use RNA-sequencing data and public genomic studies to investigate shared patterns of gene expression across neurological and neuropsychiatric diseases, with a focus on reproducible molecular mechanisms.
Interests
I love literature, F1 racing, and tennis. In my free time, I can be found involved in a political debate, watching movies, or writing my heart out.
PhD Researcher
Prathamesh Shelke
GATE (BT & XL), CSIR-NET LS
I study how exon architecture, alternative translation and untranslated regions contribute to proteoform diversity across evolutionary lineages. I also investigate how global protein folds and local residue geometry shape catalytic function.
Interests
Backpacking, Cooking, Cafe Hopping, Binge-watching
PhD Researcher
Vamika Karn
CSIR-NET - JRF & LS, GATE-BT
I work on computational multiomics integration to uncover molecular mechanisms of cancer by harmonizing different types of data for biomarker discovery and identification of potential therapeutic targets.
Interests
My interests include reading books and watching movies and series as I enjoy exploring new stories, ideas, and perspectives.
Project Associate
Abhas Wasnik
GATE-BT
I use molecular dynamics simulations to study structural differences between alternatively spliced isoenzymes of low-molecular-weight phosphotyrosyl phosphatase (LMW-PTP), and how these differences affect substrate and inhibitor interactions.
Interests
F1 Racing, Cafe Hopping, Philosophy, Politics
BS-MS Researcher
Anuska Roy
NEET-UG, JEE-Mains, and IAT
I investigate functional differences among alternatively spliced protein isoforms in cancer datasets, focusing on cancer-associated functions and their potential therapeutic relevance.
Interests
Photography and capturing moments, Reading fiction, and watching movies and web series.
Alumni
Past group members
Previous group members and their research projects.
Deeksha Thakur
PhD Researcher
Investigated sequence and structural features that distinguish substrate-promiscuous enzymes from specialists. Now doing postdoc with Arne Elofsson (https://bioinfo.se/) as SciLifeLab Pulse Fellow. Personal site: deekshatcb.github.io/deeksha
Paras Verma
PhD Researcher
Studied protein alterations in higher eukaryotes and the effects of the resulting diversity. Now doing postdoc with Monika Sharma in Plaksha University (msplaksha.github.io/mosaic). Personal site: parasvcb.github.io/paras
Preeti Choudhary
PhD (PH12018)
Large-scale structural analysis of enzymes to understand the basis of enzyme promiscuity. Now senior project manager and bioinformatics scientist in EMBL-EBI.
Rivi Verma
PhD (PH12107)
Structural conservation of intra-chain domain-domain interfaces and lessons for interface modelling. Currently doing research in punjab university.
Shabduli Sawant
Int. PhD (18030)
Worked on Pyruvate Kinase and MXEs
Irfan Kalam
BS-MS (17102)
Effects of single-residue mutations on protein structure networks
Ketika Garg
BS-MS (12062)
Evolutionary origin of specificity in triosephosphate isomerase and protein-ligand interaction features
Mridul Bazira
BS-MS (13044)
Alternate metabolic pathways in single-gene deletion strains of E. coli
Sanat Mishra
BS-MS (17107)
Consequences of de novo edited genes in the K562 leukaemia cell line
G. Sreenivas
BS-MS (16009)
Single-residue mutations in residue-interaction networks
Srishti Batra
BS-MS (09126)
Protein-ligand interactions through a ligand-centric approach
Tejendra
BS-MS (16092)
Tertiary-contact conservation among structurally related proteins
Vidisha
BS-MS (17105)
Allostery in dipeptidyl peptidase IV