Research
Our group is involved in multiple research projects. Snapshots of these projects are described below.
01Catalysis
Deciphering the structural basis of enzyme promiscuity
We study the structural basis of enzyme promiscuity by comparing substrate-promiscuous and specialist enzymes.
02Structural modelling
Analyses and modelling of domain-domain interfaces
We analyse domain-domain interfaces and use their structural conservation to improve the modelling of multidomain proteins.
03Biomaterials
Understanding the ultimate tensile strength of spider silk
We relate spider-silk sequences and nanoscale packing to the mechanical strength of silk beta-sheet nanocrystals.
04Proteogenomics
Structural consequences of alternative splicing
We study the structural and proteomic consequences of alternative splicing and the diversity generated by different exon combinations.
05Method development
Prediction of catalytic residues
CSmetaPred is a consensus approach for predicting and ranking catalytic residues in protein structures.
06Collaborative research
Collaborative and other group projects
Our collaborative work uses molecular dynamics, docking and structural analyses to address diverse questions in protein function.